Michael Henderson "Mike" Spence (30 December 1936, Croydon, Surrey – 7 May 1968, Indianapolis, Indiana, United States) was a British racing driver from England. He participated in 37 Formula One World Championship Grands Prix, debuting on 8 September 1963. He achieved 1 podium, and scored a total of 27 championship points. He also participated in numerous non-Championship Formula One races, as well as sports car and Indianapolis racing.
Spence was killed during practice for the 1968 Indianapolis 500.